How do you dilute liposomal amphotericin B?
How do you dilute liposomal amphotericin B?
Add 12 ml of Sterile Water for Injection to each AmBisome vial, to yield a preparation containing 4 mg/ml amphotericin. 2. IMMEDIATELY after the addition of water, SHAKE THE VIAL VIGOROUSLY for 30 seconds to completely disperse the AmBisome. After reconstitution the concentrate is a translucent, yellow dispersion.
How do you dilute amphotericin B injections?
Dilute each ‘mg’ of drug with 10 ml. [1 mg/ 10 ml ] [4 – 6 hours] * dilute the reconstituted solution with 250-500 mL D5W; final concentration should not exceed 0.1 mg/mL (peripheral infusion) or 0.25 mg/mL (central infusion). Add 10 mL of SWFI (without a bacteriostatic agent) to each vial of amphotericin B.
How do you make amphotericin B solution?
A stock solution may be made by dissolving the amphotericin B in the solvent of choice, which should be purged with an inert gas. Amphotericin B is soluble in the organic solvent DMSO at a concentration of approximately 2 mg/ml. Amphotericin B is sparingly soluble in aqueous buffers.
How do you administer amphotericin B emulsion?
DOSAGE AND ADMINISTRATION: Dosage: The recommended daily dosage for adults and children is 5 mg/kg given as a single infusion, administered intravenously at a rate of about 2.5 mg/kg/hour.
How do you give amphotericin B in mucormycosis?
The drug of choice for initial therapy of mucormycosis is a lipid formulation of amphotericin B. The usual starting dose is 5 mg/kg daily of liposomal amphotericin B or amphotericin B lipid complex, and many clinicians will increase the dose up as high as 10 mg/kg daily in an attempt to control this infection.
How do you administer amphotericin B bladder irrigation?
While the catheter is in your bladder, remove the cap from the end of the syringe and place the tip of it into the end of the catheter. 6. Slowly pour the Amphotericin B from the specimen cup into the syringe. Allow the solution to flow by gravity by holding the syringe higher than the level of the bladder.
Can amphotericin diluted with normal saline?
Aseptically add 12 mL of Sterile Water for Injection, USP to each AmBisome vial to yield a preparation containing 4 mg amphotericin B/mL. CAUTION: DO NOT RECONSTITUTE WITH SALINE OR ADD SALINE TO THE RECONSTITUTED CONCENTRATION, OR MIX WITH OTHER DRUGS.
How do you administer IV amphotericin?
Amphotericin B injection comes as a solid powder cake to be made into a solution and then injected intravenously (into a vein) by a nurse or a doctor. Amphotericin B injection is usually infused (injected slowly) intravenously over a period of 2 to 6 hours once daily.
What is liposomal form?
(LY-poh-SOH-mul) A drug preparation that contains the active drug inside very tiny, fat-like particles. This form is easier for the body to absorb and allows more drug to get to the target area of the body, such as a tumor. Liposomal drugs may have fewer side effects and work better than other forms of the drug.
Is amphotericin B soluble in water?
It is soluble in dimethylformamide, in dimethyl sulfoxide, and in propylene glycol, and slightly soluble in methyl alcohol Noble et al (2002). While amphotericin B is insoluble in water at pH 6-7, it is soluble at pH 2 or pH 11 at about 0.1 mg/ml. Water solubility is increased by sodium desoxycholate.
How do you administer amphotericin B lipid complex?
Amphotericin B lipid complex injection comes as a suspension (liquid) to be injected intravenously (into a vein). It is usually infused (injected slowly) intravenously once daily. The length of your treatment depends on your general health, how you tolerate the medication, and the type of infection you have.