What is the wobble rule?

Definition. The Wobble hypothesis proposes that normal base pairing can occur between nitrogen bases in positions 1 and 2 of the codon and the corresponding bases (3 and 2) in the anticodon. Actually, the base 1 in anticodon can form non-Watson-Crick base pairing with the third position of the codon.

Is the wobble position on the codon or anticodon?

The nucleotide in position 34 (so-called ‘wobble’ position) pairs with the third mRNA codon base in the aminoacyl-tRNA binding site (A-site) during decoding4,8. The nucleotide in the position 37 is adjacent to the 3′-side of the anticodon.

What is a wobble in DNA?

Describes the redundancy in the genetic code such that the same amino acid may be encoded by multiple codons.

What does wobble mean in the context of codon tRNA interaction?

According to this hypothesis, only the first two bases of the codon have a precise pairing with the bases of the anticodon of tRNA, while the pairing between the third bases of codon and anticodon may Wobble (wobble means to sway or move unsteadily).

Which base of a codon is called wobble base?

The four main wobble base pairs are guanine-uracil (G-U), hypoxanthine-uracil (I-U), hypoxanthine-adenine (I-A), and hypoxanthine-cytosine (I-C).

Why is wobble position less critical?

Wobble. Pairing of the tRNA anticodon with the mRNA codon proceeds from the 5′ end of the codon. Once the first two positions are paired, exact base pairing of the third position is less critical. This allows mRNA to be translated with fewer than the 64 tRNAs that would be required without wobble.

Why wobble is beneficial to the cell economy?

This flexibility at the “wobble” position allows some tRNAs to pair with two or three codons, thereby reducing the number of tRNAs required for translation.

What is the purpose of wobble pairing?

The Wobble Hypothesis explains why multiple codons can code for a single amino acid. One tRNA molecule (with one amino acid attached) can recognise and bind to more than one codon, due to the less-precise base pairs that can arise between the 3rd base of the codon and the base at the 1st position on the anticodon.

What is wobble hypothesis Slideshare?

CONCLUSION The Wobble Hypothesis, by Francis Crick, states that the 3rd base in an mRNA codon can undergo non-Watson-Crick base pairing with the 1st base of a tRNA anticodon The mRNA codon’s first 2 bases form Hydrogen bonds with their corresponding bases on the tRNA anticodon in the usual Watson-Crick manner, in that …

How many possible codons are there?

The cell reads the sequence of the gene in groups of three bases. There are 64 different codons: 61 specify amino acids while the remaining three are used as stop signals.

Why are there 64 codons for 20 amino acids?

The three-letter nature of codons means that the four nucleotides found in mRNA — A, U, G, and C — can produce a total of 64 different combinations. Because there are only 20 different amino acids but 64 possible codons, most amino acids are indicated by more than one codon.