What class of drug is remifentanil?

Because of its unique metabolic pathway among this group of drugs, remifentanil represents a new pharmacokinetic class of opioids which is named esterase metabolised opioid (EMO).

How do you mix remifentanil for infusion?

For manually-controlled infusion Remifentanil can be diluted to concentrations of 20 to 250 micrograms/ml (50 micrograms/ml is the recommended dilution for adults and 20 to 25 micrograms/ml for paediatric patients aged 1 year and over). For TCI the recommended dilution of Remifentanil is 20 to 50 micrograms /ml.

How do you calculate remifentanil?

We suggest a simple formula to quickly calculate the rate in ml/h:For adults, the recommended dilution is 50 μg/ml. Multiply the weight (in kg) by 0.12 to give the rate in ml/h that equates to 0.1 μg/kg/min. From this, the rates for 0.2 – 1 μg/kg/min can be rapidly calculated.

What do you mix remifentanil with?

Remifentanil should be administered with a standard dose of an hypnotic agent, such as propofol, thiopentone, or isoflurane, for the induction of anaesthesia. Administering Remifentanil after an hypnotic agent will reduce the incidence of muscle rigidity.

Is epidural or remifentanil better?

Recent studies show that epidural analgesia is superior to remifentanil patient controlled analgesia in terms of pain intensity score; however there was no difference in satisfaction with pain relief between both treatments.

Does remifentanil lower BP?

We observed that remifentanil infusion leads to a decrease in blood pressure and heart rate.

Is remifentanil water soluble?

It is a weak base with a pKa of 7.07. It is highly lipid-soluble with an octanol/water partition coefficient of 19.9 at pH 7.4.

Does remifentanil cause constipation?

This medicine may be habit-forming. If you feel that the medicine is not working as well, do not use more than your prescribed dose. Call your doctor for instructions. Using narcotics for a long time can cause severe constipation.

Can you bolus remifentanil?

The UK data sheet indicates that remifentanil may be administered as a bolus of 0.5–1.0 μg kg−1 min−1 over not less than 30 s during induction of anaesthesia. Even under these controlled conditions, this practice has not found wide acclaim because of the associated incidence of hypotension and bradycardia.

How fast do you push Propofol?

When DIPRIVAN is administered slowly over 3 minutes to 5 minutes, most patients will be adequately sedated, and the peak drug effect can be achieved while minimizing undesirable cardiorespiratory effects occurring at high plasma levels.

Does remifentanil affect baby?

Remifentanil can make you feel sleepy, sick, dizzy or itchy. These stop once you stop taking the medicine. Like pethidine, remifentanil can affect the baby’s breathing but this usually wears off quickly.

What are the side effects of Versed?

Common side effects may include:

• amnesia;
• headache, drowsiness;
• hiccups;
• nausea, vomiting; or.
• pain, redness, or a hard lump where the medicine was injected.