Is A1C accurate in thalassemia?

Is A1C accurate in thalassemia?

Conclusions: S-beta(+)-thalassemia interferes with Bio-Rad Turbo assay causing falsely elevated A1c. If significantly increased A1c is detected and HbS is >50%, S-beta(+)-thalassemia should be suspected.

What blood conditions affect A1C?

Editor’s note: Blood disorders that affect A1c values are more common than we may think. These disorders can include sickle cell trait, thalassemia, and some forms of anemia.

What does a high hemoglobin A1C level mean?

If your HbA1c levels are high, it may be a sign of diabetes, a chronic condition that can cause serious health problems, including heart disease, kidney disease, and nerve damage. Other names: HbA1c, A1c, glycohemoglobin, glycated hemoglobin, glycosylated hemoglobin.

What does hemoglobin A1C indicate?

The A1C test—also known as the hemoglobin A1C or HbA1c test—is a simple blood test that measures your average blood sugar levels over the past 3 months. It’s one of the commonly used tests to diagnose prediabetes and diabetes, and is also the main test to help you and your health care team manage your diabetes.

Can thalassemia minor affect A1c?

The laboratory findings, which are not characteristic of beta-thalassemia minor, could be the cause of the markedly low hemoglobin A1c in this patient. Conclusions: Although rare, when associated with marked erythrocyte turnover, beta-thalassemia minor can lead to a severe reduction in HbA1c levels.

What can cause a false high A1c?

A falsely high A1C result can occur in people who are very low in iron; for example, those with iron-deficiency anemia link. Other causes of false A1C results include kidney failure or liver disease.

What can falsely elevate A1C?

Several medications and substances have also been reported to falsely elevate A1c including lead poisoning2, chronic ingestion of alcohol, salicylates, and opioids. Ingestion of vitamin C may increase A1c when measured by electrophoresis, but may decrease levels when measured by chromatography.

Does thalassemia cause high HbA1c?

Within the group of β-thalassemia, there was a positive correlation between HbA1c and hemoglobin concentration (r = 0.455, p < 0.001), which was not observed in controls. β-thalassemia carriers without anemia had slightly higher HbA1c levels compared to those with anemia (34.9 mmol/mol [5.35%] vs.

How is fructosamine converted to A1c?

The correlated formula about estimated fructosamine values was obtained from our results: estimated fructosamine=48.55×HbA1c-5.84 (Fig.