What is fisetin used for?
What is fisetin used for?
Fisetin (3,3′,4′,7-tetrahydroxyflavone) is a dietary flavonoid found in various fruits (strawberries, apples, mangoes, persimmons, kiwis, and grapes), vegetables (tomatoes, onions, and cucumbers), nuts, and wine that has shown strong anti-inflammatory, anti-oxidant, anti-tumorigenic, anti-invasive, anti-angiogenic.
How do you take fisetin?
I use this by taking 1 pill a day and have used it twice as a senolytic. To take as a senolytic I recommend using the Mayo clinics latest study on frailty which doses at 20mg per KG of body weight. For me that was a 2100mg dose. I took it in olive oil and Bioperine (black pepper extract) for increased absorption.
How much fisetin is in strawberries?
The highest concentration of fisetin was found in strawberries (160 μg/g) followed by apple (26.9 μg/g) and persimmon (10.5 μg/g) (33). Other dietary sources of fisetin and their concentrations are provided in Figure 2.
What is similar to apigenin?
Fisetin 500mg – 98% Pure Fisetin Supplement (Similar to Apigenin, Luteolin, Quercetin) Senolytic Activator – Sirtuin Activator – Bioflavonoid Polyphenols – Non-GMO, Vegan, Soy Free – by Humanx.
How much fisetin should I take?
In an ongoing clinical trial looking at the effects of fisetin on inflammation, bone health, and frailty in the elderly, fisetin will be used at a high dosage of 20 mg/kg for two consecutive days. This would be around 1,400 mg/day for a 155-lbs person .
Is fisetin anti-inflammatory?
Fisetin also has anti-inflammatory activity both in vitro and in vivo that fisetin reduced the level of inflammatory cytokines TNFα, IL-1β and IL-6 in UVB-exposed skin (33). Fisetin has been suggested to perform its role in suppressing tumor growth by regulating DNA and apoptosis (34).
Is fisetin worth taking?
Fisetin is a promising senolytic that might help the body get rid of toxic, senescent cells that cause aging. Plus, according to preclinical research, it may protect the brain and heart, improve memory, and combat inflammation and free-radical damage.
What are the side effects of fisetin?
Safety: There is no evidence that fisetin would cause side effects, but no studies in humans have been conducted. There is no safety data for fisetin supplementation in humans, though no toxicity in animals has been reported.
Do blueberries have fisetin?
Maher acknowledges that the public may be suffering from flavonoid-fatigue, given media coverage of the promises of these compounds. “Polyphenolics like fisetin and those in blueberry extracts are found in fruits and vegetables and are related to each other chemically,” she says.
What is the best source of fisetin?
Strawberries are by far the best food source of fisetin, followed by apples and persimmons.
Is Fisetin the same as apigenin?
Apigenin, one of the most common flavonoids found in fruits and vegetables, is also called 5, 7, 4′-trihydroxyflavone. Luteolin and Fisetin are also known as 5, 7, 3′, 4′-trihydroxyflavone and 3, 7, 3′, 4′-tetrahydroxyflavone, respectively.