What does agmatine sulfate do?

Overview. Agmatine is a chemical found in bacteria, plants, and animals, including humans. It is made from the amino acid known as arginine. Agmatine is commonly used by mouth for depression, nerve pain, improving athletic performance, and many more conditions.

When should I take agmatine sulfate?

A daily dose of 2.67 g agmatine sulfate was encapsulated in gelatin capsules; the regimen consists of six capsules daily, each containing 445 mg, three in the morning and three in the evening after meals. Clinical follow-up consists of periodic physical examinations and laboratory blood and urine analyses.

How much agmatine can you take?

Dosage. There is currently no standard dosage for agmatine sulfate because there haven’t been enough human studies to determine one. However, studies on neuropathic pain provided between 1 g and 2.5 g of agmatine per day.

How long does agmatine stay in your system?

Rapid elimination from non-brain organs of ingested (un-metabolized) agmatine by the kidneys has indicated a blood half life of about 2 hours.

Does agmatine sulfate cause weight gain?

Influence on Body Weight Gain and Tissue Fat or Protein Mass. The consumption of AGM resulted in about a 15% reduction in body weight (BW) gain between 30 and 55 days in HFD + AGM or SD + AGM compared with the HFD or SD study group, respectively (Fig. 1d).

Is agmatine sulfate banned?

It was not banned for safety reasons, rather some odd EU rule that since it was not sold before 1997, it now needs to go through an approval process, that someone would have to pay for, before it can continue to be sold. Agmatine is not such an effective body building supplement to warrant anyone investing much in it.

Which is better arginine or agmatine?

‘ Arginine, a BCAA, is thought to increase nitric oxide (nNOS and eNOS). Agmatine, on the other hand, decreases nNOS, and so the two do not play nice. By reducing the effectiveness of agmatine, arginine inhibits the neurological and physiological benefits you get from the chemical.

Does agmatine help anxiety?

Agmatine attenuates chronic unpredictable mild stress-induced anxiety, depression-like behaviours and cognitive impairment by modulating nitrergic signalling pathway. Brain Res.

Does agmatine increase dopamine?

In addition, agmatine treatment in control mice increased noradrenaline, serotonin, and dopamine levels, CREB phosphorylation, mature BDNF and synaptotagmin I immunocontents, and reduced pro-BDNF immunocontent in the hippocampus.

Can Agmatine cause anxiety?

Agmatine (20 and 40mg/kg, i.p.) alone and in combination with NO modulators like L-NAME (15mg/kg, i.p.) and l-arginine (400mg/kg i.p.) were administered daily. The results showed that 4-weeks CUMS produces significant depression and anxiety-like behaviour.

Can you take arginine and agmatine together?

Agmatine is synthesized from arginine. However, agmatine does not function well with arginine because it will offset the effects of the agmatine by reducing its inhibition of nNOS (nitric-oxide synthase).