What does LogP value tell you?
What does LogP value tell you?
The Log P value of the compound indicates the permeability of the drugs to reach the target tissue in the body. All the investigated compounds are lipophilic because the Log P > 0 (or P > 1) (Table 3).
What is LogP chemistry?
1.1 Lipophilicity. Lipophilicity, most commonly referred to as the LogP, represents the ratio at equilibrium of the concentration of a compound between two phases, an oil and a liquid phase (Bohnert and Prakash, 2012).
Is 0.007 statistically significant?
at the margin of statistical significance (p<0.07) close to being statistically significant (p=0.055) only slightly non-significant (p=0.0738) provisionally significant (p=0.073)
What does a high logP mean?
A negative value for logP means the compound has a higher affinity for the aqueous phase (it is more hydrophilic); when logP = 0 the compound is equally partitioned between the lipid and aqueous phases; a positive value for logP denotes a higher concentration in the lipid phase (i.e., the compound is more lipophilic).
What is good solubility for a drug?
A drug is considered highly soluble when the highest dose strength is soluble in 250 mL or less of aqueous media over the pH range of 1 to 7.5.
What does a low LogP mean?
What is LogD vs LogP?
logD is a log of partition of a chemical compound between the lipid and aqueous phases. LogP is equivalent to logD for non-ionisable compounds and represents the partition of the neutral form for ionizable compounds (and, hence, is a virtual, unmeasurable, property).
What does a high value of distribution coefficient signify?
The value is greater than one if a substance is more soluble in fat-like solvents such as n-octanol, and less than one if it is more soluble in water.
What is a good solubility value?
A drug is considered highly soluble when the highest dose strength is soluble in 250 mL or less of aqueous media over the pH range of 1 to 7.5….Table 1.
| Descriptive term | Part of solvent required per part of solute |
|---|---|
| Sparingly soluble | From 30 to 100 |
| Slightly soluble | From 100 to 1000 |
Which form of drug shows highest solubility?
Drug in amorphous state Poor water soluble crystalline drugs in amorphous state tend to have higher solubility. [20] This is because no energy is required to break crystal lattice in amorphous state during dissolution.