What is MIB 1 proliferation index?

The MIB-1 labeling index was defined as the percentage of immunoreactive tumor cells in the evaluated area. Vascular components and hematogenous cells were excluded. The evaluated areas also excluded necrotic, degenerated, and poorly preserved areas.

How do you interpret ki67?

A staining process can measure the percentage of tumor cells that are positive for Ki-67. The more positive cells there are, the more quickly they are dividing and forming new cells. In breast cancer, a result of less than 10% is considered low, 10-20% borderline, and high if more than 20%.

What is a proliferative tumor?

Listen to pronunciation. (proh-LIH-feh-ruh-tiv …) A measure of the number of cells in a tumor that are dividing (proliferating). May be used with the S-phase fraction to give a more complete understanding of how fast a tumor is growing.

What does Synaptophysin positive mean?

Immunohistochemical stains synaptophysin, chromogranin and TTF1 are positive in the tumor cells. These findings support the diagnosis of small cell neuroendocrine carcinoma of the lung.

Does a high Ki-67 score alone mean that I have a malignant Tumour?

Your oncologist usually takes several test results into account when trying to understand your unique cancer. Some studies have found that tumors with higher levels of Ki-67 may have a worse prognosis than tumors with lower levels.

What does it mean if a cell is proliferative?

Listen to pronunciation. (sel proh-LIH-feh-RAY-shun) An increase in the number of cells as a result of cell growth and cell division.

Is a Grade 1 neuroendocrine tumor malignant?

The World Health Organization (WHO) classifies neuroendocrine tumors according to the malignant potential of the tumor: Well-differentiated neuroendocrine tumors (grade 1 and 2) Poorly-differentiated neuroendocrine tumors (grade 3)

What does s100 positive mean?

S-100 protein (S-100B) is the most widely used marker for peripheral nerve sheath tumors. Although S-100 protein is positive in all benign Schwann cell tumors, this marker shows relatively low sensitivity for MPNST (at most, around 50%).

How reliable is Ki-67?

Ki-67 assessed by using method A with a cut-off of 10% was a predictive marker for OS, as the hazard ratio (>10% vs. <=10%) in patients with chemotherapy was 0.48 with a 95% confidence interval of [0.19–1.19].