What drugs are TNF-alpha inhibitors?

Tumor necrosis factor (TNF)-alpha inhibitors, including etanercept (E), infliximab (I), adalimumab (A), certolizumab pegol (C), and golimumab (G), are biologic agents which are FDA-approved to treat ankylosing spondylitis (E, I, A, C, and G), Crohn disease (I, A and C), hidradenitis suppurativa (A), juvenile idiopathic …

What is the best TNF blocker?

All five TNF inhibitors currently available on the market (i.e., etanercept, infliximab, adalimumab, certolizumab and golimumab) are top sellers, although indicated only in autoimmune diseases, including rheumatoid arthritis, Crohn’s disease and psoriasis.

What is the safest TNF blocker?

Combining results from studies involving nearly 12,000 rheumatoid arthritis patients finds the fusion protein etanercept less likely than other TNF inhibitors to be discontinued due to infections.

Is Methotrexate a TNF blocker?

Methotrexate primarily inhibits the activation and proliferation of lymphocytes. TNF inhibitors suppress monocytes and myeloid dendritic cells, and tocilizumab has a broader activity and is directed against both the lymphoid as well as the myeloid compartment.

Is hydroxychloroquine a TNF inhibitor?

Your doctor may have you use a TNF inhibitor in combination with other drugs, such as methotrexate, prednisone, hydroxychloroquine (Plaquenil), leflunomide (Arava), or sulfasalazine (Azulfidine).

Is sulfasalazine a TNF blocker?

The antiinflammatory drug sulfasalazine inhibits tumor necrosis factor alpha expression in macrophages by inducing apoptosis. Arthritis Rheum.

Is Skyrizi a TNF blocker?

(A drug class is a group of medications that work in a similar way.) The active drug in Humira is adalimumab. Humira belongs to a drug class called tumor necrosis factor (TNF) blockers. Skyrizi and Humira are both biologic drugs, which means they’re made from living cells.

What are the side effects of TNF inhibitors?

The important side effects of TNF inhibitors include lymphomas, infections (especially reactivation of latent tuberculosis), congestive heart failure, demyelinating disease, a lupus-like syndrome, induction of auto-antibodies, injection site reactions, and systemic side effects.

Is prednisone a TNF blocker?

Are TNF inhibitors immunosuppressants?

TNF blockers include infliximab (Remicade), etanercept (Enbrel), adalimumab (Humira), certolizumab pegol (Cimzia), and golimumab (Simponi). Other immunosuppressants that have been associated with the development of HSTCL are azathioprine (Azasan, Imuran) and mercaptopurine (Purinethol).