What is transcriptional network?
What is transcriptional network?
With gene expression microarray technologies, it is factible to construct transcriptional networks where nodes are transcribed genes, and links represent a correlation between expression values of said genes, which point to a possible interaction between them at the transcriptional level (Tovar et al., 2015).
What are the two types of transcriptional control?
Some post-translational modifications known to regulate the functional state of transcription factors are phosphorylation, acetylation, SUMOylation and ubiquitylation. Transcription factors can be divided in two main categories: activators and repressors.
What is the role of transcriptional factors?
Transcription factors are proteins involved in the process of converting, or transcribing, DNA into RNA. Regulation of transcription is the most common form of gene control. The action of transcription factors allows for unique expression of each gene in different cell types and during development.
What is a transcriptional program?
The transcriptional programs it identifies potentially represent common mechanisms of regulatory control across the genome. It simultaneously predicts which genes are co-regulated and which sets of transcription factors cooperate to achieve this co-regulation.
How do you improve transcription?
Key Terms
- enhancer: a short region of DNA that can increase transcription of genes.
- repressor: any protein that binds to DNA and thus regulates the expression of genes by decreasing the rate of transcription.
- activator: any chemical or agent which regulates one or more genes by increasing the rate of transcription.
How do transcription factors play a role in transcriptional regulation?
Transcription factors (TFs) are regulatory proteins whose function is to activate (or more rarely, to inhibit) transcription of DNA by binding to specific DNA sequences. TFs have defined DNA-binding domains with up to 106-fold higher affinity for their target sequences than for the remainder of the DNA strand.
How do you determine if a protein is a transcription factor?
To qualify as a transcription factor, a protein must possess two qualities. 1) Ability to bind to DNA and 2) recruit RNA polymerase/alter transcription of a gene.
How is the process of transcription regulated?
First, transcription is controlled by limiting the amount of mRNA that is produced from a particular gene. The second level of control is through post-transcriptional events that regulate the translation of mRNA into proteins. Even after a protein is made, post-translational modifications can affect its activity.