What is Nephroprotective effect?

]. Nephroprotective agents are material that has potential to minimize the effects of nephrotoxic agents. Medicinal plants have curative properties due to the presence of various complex chemical substances [22.

Why are ACE inhibitors Nephroprotective?

Some evidence indicates that the renal-protective effects of ACE inhibitors results from their effects on glomerular growth and glomerular permselectivity. The role of reduced generation of angiotensin II or accumulation of kinins in the renal effects of ACE inhibitors is under investigation.

What is Renoprotective?

[re″no-pro-tek´tiv] protecting the kidney against harmful effects such as of a drug or other chemical.

What causes nephrotoxicity?

Nephrotoxicity defined as a renal disease or dysfunction, is often caused by drugs, chemicals, industrial, or environmental toxic agents.

How do ACE inhibitors work?

ACE inhibitors prevent an enzyme in the body from producing angiotensin II, a substance that narrows blood vessels. This narrowing can cause high blood pressure and forces the heart to work harder. Angiotensin II also releases hormones that raise blood pressure.

Why are ACE inhibitors used in CKD?

ACE inhibitors effectively reduce systemic vascular resistance in patients with hypertension, heart failure or chronic renal disease. This antihypertensive efficacy probably accounts for an important part of their long term renoprotective effects in patients with diabetic and non-diabetic renal disease.

Why are ACE inhibitors Renoprotective?

Are SGLT2 inhibitors Renoprotective?

Beyond the hypoglycemic effects, SGLT2 inhibition has renoprotective properties.

What causes ototoxicity and nephrotoxicity?

The aminoglycoside antibiotic gentamicin can cause both ototoxicity and nephrotoxicity, the severity of which varies with circadian time of daily treatment.

What causes ototoxicity?

Ototoxicity is when a person develops hearing or balance problems due to a medicine. This can happen when someone is on a high dose of a drug that treats cancer, infections, or other illnesses.

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