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What does FOXO1 stand for?

What does FOXO1 stand for?

Forkhead box protein O1 (FOXO1), also known as forkhead in rhabdomyosarcoma (FKHR), is a protein that in humans is encoded by the FOXO1 gene.

What is FOXO1 gene?

FOXO1 (Forkhead Box O1) is a Protein Coding gene. Diseases associated with FOXO1 include Rhabdomyosarcoma 2 and Glioma. Among its related pathways are Immune response IL-23 signaling pathway and Regulation of beta-cell development.

What do FOXO proteins do?

Members of class O (FOXO- proteins) regulate metabolism, cellular proliferation, stress tolerance and possibly lifespan. The activity of FoxO is controlled by post-translational modifications, including phosphorylation, acetylation and ubiquitination.

What is the FOXO3 gene?

FOXO3 (Forkhead Box O3) is a Protein Coding gene. Diseases associated with FOXO3 include Aging and Chromosome 6Q Deletion. Among its related pathways are DNA Damage Response (only ATM dependent) and Beta-Adrenergic Signaling.

What type of transcription factor is FoxO1?

The FOXO family is a subclass of Forkhead transcription factors characterized by a winged helix DNA binding domain known as a Forkhead box [4].

How is FoxO1 regulated?

FoxO1 is a conserved transcription factor involved in energy metabolism. It is tightly regulated by modifications on its mRNA and protein and responds to environmental nutrient signals. FoxO1 controls the transcription of downstream genes mediating metabolic regulation.

How does insulin regulate FoxO1?

Insulin also inactivates FoxO1, which positively regulates PGC1α expression at the transcriptional level by binding to three insulin response elements (IREs) in its promoter (Daitoku et al., 2003).

How is FoxO1 activated?

FOXO1 is activated by bacterial or cytokine stimulation. Its translocation to the nucleus and binding to promoter regions of genes that have FOXO response elements is stimulated by the MAP kinase pathway and inhibited by the PI3 kinase/AKT pathway.

Where is FOXO3 located?

The FOXO3a gene is located on chromosome 6q21 [13] and it plays vital role in regulating a variety of cellular processes through targeting the expression and activity of effector genes. The subcellular localization of FOXO3a is important for its activities and functions [14].

Does everyone have FOXO3 gene?

“All of us have the FOXO3 gene, which protects against aging in humans,” said Dr. By activating the FOXO3 gene common in all humans, we can make it act like the “longevity” version. Through this research, we have shown that Astaxanthin “activates” the FOXO3 gene,” said Willcox.

What is dFoxO?

dFoxO, the equivalent of nematode DAF‐16/FoxO and mammalian FOXO3A, has been shown to be a key transcriptional regulator of the insulin pathway that modulates growth and proliferation in D. melanogaster (Puig & Mattila, 2011).

Where is ChREBP located?

ChREBP (a basic-helix-loop-helix leucine zipper protein) leads to formation of a heterodimer with a Max-like protein (MLX) [8], [9], [10]. ChREBP is expressed in the liver, white adipose tissues (WATs), brown adipose tissues (BATs), the intestine, muscle, and pancreatic β-cells [7], [11].

Forkhead box protein O1 ( FOXO1 ), also known as forkhead in rhabdomyosarcoma ( FKHR ), is a protein that in humans is encoded by the FOXO1 gene.

What is the role of FOXO1 in carcinogenesis?

In Carcinogenesis, FOXO1 plays a role of a tumor suppressor and its inactivation has been documented in many kinds of human cancer. It suppresses survival of tumor cells by inducing apoptosis in prostate cancer cells and glioma cells by upregulating the proapoptotic factors.

Is FOXO1 a target for genetic control of type 2 diabetes?

Because FOXO1 provides a link between transcription and metabolic control by insulin, it is also a potential target for genetic control of type 2 diabetes.

What is the role of FOXO1 transcription factor in wound healing?

Wound healing is a very complicated biological process and studies have indicated that FOXO1 transcription factor helps in orchestrating events that enhance the healing process in keratinocytes. Localization of FOXO1 nuclear increased four times in wound-healing keratinocytes.