What are granulomatous infections?

Overview. Chronic granulomatous (gran-u-LOM-uh-tus) disease (CGD) is an inherited disorder that occurs when a type of white blood cell (phagocyte) that usually helps your body fight infections doesn’t work properly. As a result, the phagocytes can’t protect your body from bacterial and fungal infections.

What causes granulomatous infection?

Chronic granulomatous disease is a genetic disorder and is caused by inherited defects in an important enzyme in white blood cells that manufactures oxidants for microbial killing.

What is the treatment for granulomatous disease?

Chronic granulomatous disease is usually managed with antibiotic and antifungal medications to treat and prevent infection. Corticosteriods may be used to shrink granulomas (areas of inflamed tissue ). Treatment may also include a medication called Actimmune (also known as interferon gamma-1b).

Is granulomatous disease the same as sarcoidosis?

PURPOSE: Granulomatous diseases comprise a heterogeneous group of disorders. Sarcoidosis and Common Variable Immunodeficiency (CVID) affect the same organs with granuloma and their histological appearance is indistinguishable.

Is granuloma a tumor?

A granuloma is a tiny cluster of white blood cells and other tissue that can be found in the lungs, head, skin or other parts of the body in some people. Granulomas are not cancerous. They form as a reaction to infections, inflammation, irritants or foreign objects.

Can granulomas cause pain?

Symptoms of Lung Granulomas Some of these include: Shortness of breath. Wheezing. Chest pain.

How long can you live with granulomatous disease?

Prognosis. When CGD was initially discovered, patients rarely survived into adulthood. Now, however, the survival of the disease has dramatically improved and the average survival for patients with CGD is 40 years.