Users' questions

Is corticosterone soluble in water?

Is corticosterone soluble in water?

Solubility (25°C)

In vitro Batch: S475203 S475202 S475201 DMSO 69 mg/mL (199.16 mM)
Water Insoluble
Ethanol (warmed with 50ºC water bath) 9 mg/mL (25.98 mM)

Is cortisol soluble in water?

Cortisol is a water soluble membrane; epinephrine is lipid soluble.

What is the chemical structure of cortisol?

When used as a medication, it is known as hydrocortisone. It is produced in many animals, mainly by the zona fasciculata of the adrenal cortex in the adrenal gland….Cortisol.

Chemical formula C21H30O5
Molar mass 362.460 g/mol

How do you dissolve corticosterone?

You can dissolve corticosterone in 100% ethanol up to 10mM. This can then be diluted using something like sesame oil. I recommend heating while dissolving in ethanol. At 10mM in ethanol, corticosterone will not precipitate out of solution and can be stored for at least one month at -20C.

Where is corticosterone secreted?

adrenal cortex
Corticosterone is a steroid-based hormone of 21 carbons among adrenal corticosteroids synthesized in the adrenal cortex.

Are peptide hormones lipid-soluble?

Amino acid-derived and polypeptide hormones are water-soluble and insoluble in lipids. These hormones cannot pass through plasma membranes of cells; therefore, their receptors are found on the surface of the target cells.

Are peptide hormones water soluble?

Most water-soluble hormones, like the amino acid derivatives and peptides, can travel freely in the blood because they “like” water. However, they are repelled by lipid or fatty structures such as the membranes that surround the cell and nucleus.

How do you metabolize cortisol?

Cortisol and cortisone are metabolized by 5a-reductase and 5b-reductase (and then by another enzyme) to tetrahydrocortisol and tetrahydrocortisone for excretion. This metabolism process is particularly increased (sped up) in obesity, high insulin and hyperthyroid.

Is cortisol hydrophobic or hydrophilic?

Cortisol is a hydrophobic molecule that is largely bound to corticosteroid-binding globulin (CBG) in the circulation.