Users' questions

What is CD30 a marker for?

What is CD30 a marker for?

CD30 is a surface marker for neoplastic cells of Hodgkin’s lymphoma and shows sequence homology to members of the tumor necrosis factor (TNF) receptor superfamily.

What is CD30 positive lymphoma?

Primary cutaneous CD30-positive large cell lymphoma (CD30+ PCLCL) is a rare subtype of cutaneous T-cell lymphoma (CTCL) that can present in a variety of ways. We report a patient with a three-month history of an enlarging, exophytic mass with two smaller satellite lesions on the left forearm.

What is CD30 in cancer?

CD30 is membrane-related and Golgi perinuclear-related antigen that identifies Reed-Sternberg cell in a patient with Hodgkin lymphoma. The CD30 antigen is a receptor of tumor necrosis factor, or TNF superfamily.

Is AITL CD30 positive?

Using a CD30 cutoff of 5%, prior studies have demonstrated that 63% of patients with AITL were CD30 positive, but only 5% were strongly positive (defined as greater than 50% of cells), thus potentially contributing to some of this discrepancy.

Where is CD30 found?

CD30 is found on the malignant cells of classical Hodgkin lymphoma, a B-cell neoplasm; CD30+ ALCL, usually T-cell in origin; occasional high-grade lymphomas of T- or B-cell origin; testicular embryonal carcinoma, a nonhematopoietic tumor; and possibly undifferentiated pleomorphic sarcoma (UPS), previously called …

What is CD20 positive?

A protein found on B cells (a type of white blood cell). It may be found in higher than normal amounts in patients with certain types of B-cell lymphomas and leukemias. Measuring the amount of CD20 on blood cells may help to diagnose cancer or plan cancer treatment. CD20 is a type of tumor marker.

What is vedotin?

Brentuximab vedotin contains a monoclonal antibody that binds to a protein called CD30, which is found on some lymphoma cells. It also contains an anticancer drug, which may help kill cancer cells. Brentuximab vedotin is a type of antibody-drug conjugate. Also called Adcetris and SGN-35.

Where is CD30 located?