What is sulfotransferase enzyme?

What is sulfotransferase enzyme?

Sulfotransferases (SULTs) are transferase enzymes that catalyze the transfer of a sulfo group from a donor molecule to an acceptor alcohol or amine. In the case of alcohol as acceptor, the product is a sulfate (R-OSO3−), whereas an amine leads to a sulfamate (R-NH-SO3−).

What is SULT enzyme?

The superfamily of sulfotransferase (SULT) enzymes catalyzes the sulfate conjugation of several pharmacologically important endo- and xenobiotics. SULT1A1 catalyzes the sulfation of small planar phenols such as neurotransmitters, steroid hormones, acetaminophen, and p-nitrophenol (PNP).

Which of the following enzymes has the widest tissue distribution?

GST was the enzyme with the widest tissue distribution.

What is sulfation in the body?

Sulfation is a conjugation process and it is involved in various body processes from the biotransformation/detox pathways to biosynthesis of some proteins. Sulfation of hormones allow transport of hormones in the blood to target tissues.

Which of the following enzymes is involved in glucuronidation?

Glucuronidation occurs mainly in the liver, although the enzyme responsible for its catalysis, UDP-glucuronyltransferase, has been found in all major body organs (e.g., intestine, kidneys, brain, adrenal gland, spleen, and thymus).

Is AST a transaminase?

AST is also called SGOT (serum glutamic-oxaloacetic transaminase). Normally, AST levels in your blood are low. When your liver is damaged, it puts more AST into your blood, and your levels rise.

Where is AST made?

AST is found in the liver, heart, skeletal muscle, kidneys, brain, and red blood cells….Aspartate transaminase.

MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO