What causes microcytosis?

The most common causes of microcytosis are iron deficiency anemia and thalassemia trait. Other diagnoses to consider include anemia of chronic disease, lead toxicity, and sideroblastic anemia. Serum ferritin measurement is the first laboratory test recommended in the evaluation of microcytosis.

Why does iron deficiency cause microcytosis?

In iron deficiency anaemia, the red cells are smaller than normal (microcytosis). This is because the maturing red cells undergo an extra cellular division before the critical haemoglobin concentration required to arrest mitosis is achieved. The cells are also hypochromic, with a larger area of central pallor (see Fig.

Is microcytosis serious?

As long as the underlying cause of the anemia can be treated, the anemia itself can be treated and even cured. In very severe cases, untreated microcytic anemia can become dangerous. It can cause tissue hypoxia. This is when the tissue is deprived of oxygen.

How do you fix Microcytosis?

Treatment for microcytic anemia focuses on treating the underlying cause of the condition. Your doctor may recommend that you take iron and vitamin C supplements. The iron will help treat the anemia while the vitamin C will help increase your body’s ability to absorb the iron.

Why does Microcytosis decrease ESR?

Red cell changes are especially prone to affect ESR. If hematocrit is reduced, red cell aggregates sediment faster. The more severe the anemia the higher the ESR….Erythrocyte Sedimentation Rate (ESR)

Is Microcytosis serious?

What is macrocytosis?

Macrocytosis is a term used to describe red blood cells that are larger than normal. Also known as megalocytosis or macrocythemia, this condition typically causes no signs or symptoms and is usually detected incidentally on routine blood tests.