What does high VEGF mean?

What does high VEGF mean?

An elevated VEGF level in the serum may indicate the presence of cancer. Chronic states of hypoxia such as COPD may increase VEGF levels. In addition, people with serious or chronic wounds may have elevated VEGF levels. VEGF is produced in people with low platelet levels (thrombocytopenia).

Is VEGF an inflammatory marker?

Thus, VEGF can enhance inflammatory processes, resulting in more severe inflammation. Blocking VEGF production in chronic inflammatory diseases may become an important means of ameliorating the severity of some of these pathologies.

What is VEGF in inflammation?

VEGF is a mediator of angiogenesis and inflammation which are closely integrated processes in a number of physiological and pathological conditions including obesity, psoriasis, autoimmune diseases and tumor.

What does the protein VEGF stimulate?

Vascular endothelial growth factor (VEGF) is a signalling protein that promotes the growth of new blood vessels. VEGF forms part of the mechanism that restores the blood supply to cells and tissues when they are deprived of oxygenated blood due to compromised blood circulation.

What triggers VEGF?

VEGF-A production can be induced in a cell that is not receiving enough oxygen. When a cell is deficient in oxygen, it produces HIF, hypoxia-inducible factor, a transcription factor. HIF stimulates the release of VEGF-A, among other functions (including modulation of erythropoiesis).

What are normal VEGF levels?

Normal ranges of VEGF were 62–707 pg/ml for serum and 0–115 pg/ml for plasma respectively.

What causes VEGF?

VEGF is produced by hypertrophic chondrocytes in the growth plate where it co-ordinates extracellular matrix (ECM) remodelling, angiogenesis, and bone formation. VEGF is expressed in the synovial fluid of patients with rheumatoid arthritis.

In which other types of cancers do you expect VEGF signaling to play a role?

Not only is VEGF a major player in leukemias and lymphomas, it is also highly expressed in a variety of solid malignant tumors,59–61 and correlates with malignant disease progression. VEGF overexpression in tumors is associated with increased angiogenesis, proliferation and metastasis.