What is differentiated neuroendocrine carcinoma?

Abstract. Poorly differentiated neuroendocrine carcinomas (NECs) are rare tumors that can arise anywhere along the gastrointestinal tract. They often present in advanced stage and portend a poor prognosis when compared to adenocarcinomas of the same stage.

What is neuroendocrine colon cancer?

BACKGROUND. Colorectal neuroendocrine carcinoma (NEC) is a rare tumor that demonstrates aggressive growth pattern with ingrowth into the tract, metastasis to the other organs, and invasion to the surrounding organs; these clinical characteristics result in poor prognosis.

What are neuroendocrine cells in the colon?

Neuroendocrine marker-positive cells in cancer tissues are commonly found in the right sided colon. Although this is consistent with the preferred site of NEC, many neuroendocrine marker-positive cells reside in the normal mucosa of the rectum. These results suggest that NEC may arise from preceding adenocarcinomas.

What is moderately differentiated adenocarcinoma colon?

Conventional adenocarcinoma is characterized by glandular formation, which is the basis for histologic tumor grading. In well differentiated adenocarcinoma >95% of the tumor is gland forming. Moderately differentiated adenocarcinoma shows 50-95% gland formation.

What is a well-differentiated neuroendocrine tumor grade 1?

Grade 1. The cells look very like normal cells. Tumours are usually slow growing and less likely to spread. They are also called low grade or well differentiated tumours.

What’s the difference between colon and colorectal cancer?

Colorectal cancer is a disease in which cells in the colon or rectum grow out of control. Sometimes it is called colon cancer. The colon is the large intestine or large bowel.

Can you see carcinoid tumors in a colonoscopy?

Passing a scope through your rectum (colonoscopy) can help diagnose rectal carcinoid tumors. To see inside your small intestine, your doctor may recommend a test using a pill-sized camera that you swallow (capsule endoscopy).

What stage is well-differentiated adenocarcinoma?

Low grade or grade I tumors are well-differentiated. This means that the tumor cells are organized and look more like normal tissue. High grade or grade III tumor cells are poorly differentiated.