What is da EPOCH-R?

REH-jih-men) An abbreviation for a chemotherapy combination used to treat certain types of non-Hodgkin lymphoma. It includes the drugs etoposide phosphate, prednisone, vincristine sulfate (Oncovin), cyclophosphamide, doxorubicin hydrochloride (hydroxydaunorubicin), and rituximab.

How often is R-EPOCH given?

DA-EPOCH-R is typically repeated every 21 – 28 days. This is known as one Cycle. Each cycle may be repeated up to 8 times, depending upon the stage of the disease.

What is primary mediastinal large B cell lymphoma?

Primary mediastinal large B-cell lymphoma (PMBCL) is a type of non-Hodgkin lymphoma (NHL). It is sometimes called primary thymic mediastinal lymphoma. PMBCL develops when B-cells become abnormal (cancerous). B-cells are white blood cells that normally help fight infection.

How is epoch administered?

Original DA-EPOCH regimen (20) consists of continuous intravenous infusion of etoposide 50 mg/m2/d on days 1 to 4, oral prednisone 60 mg/m2/d on days 1 to 5, continuous infusion of vincristine (Oncovine) 0.4 mg/m2/d on days 1 to 4, cyclophosphamide 750 mg/m2/d administered intravenously over 15 minutes on day 5.

What are the side effects of R-EPOCH?

Swelling of the body. Nausea, vomiting, constipation, diarrhea, loss of appetite, pain in belly. Increased appetite and weight gain in the belly, face, back and shoulders. Sores in mouth.

What does double hit lymphoma mean?

Listen to pronunciation. (DUH-bul-hit lim-FOH-muh) A rare, aggressive (fast-growing) type of B-cell non-Hodgkin lymphoma caused by changes in the DNA that affect a gene called the MYC gene and either the BCL2 gene or the BCL6 gene. Double-hit lymphoma may be hard to treat and has a poor prognosis.

Do chemo symptoms get worse with each treatment?

Most types of pain related to chemotherapy get better or go away between treatments. However, nerve damage often gets worse with each dose. Sometimes the drug causing the nerve damage has to be stopped. It can take months or years for nerve damage from chemotherapy to improve or go away.

What drugs are in epoch?

An abbreviation for a chemotherapy combination used to treat certain types of non-Hodgkin lymphoma. It includes the drugs rituximab, etoposide phosphate, prednisone, vincristine sulfate (Oncovin), cyclophosphamide, and doxorubicin hydrochloride (hydroxydaunorubicin).

How effective is epoch?

Conclusion: EPOCH chemotherapy was well tolerated and highly effective in patients who were resistant to or relapsed from the same drugs administered on a bolus schedule, suggesting that continuous infusion of the natural drug component of this regimen is capable of partially reversing drug resistance and reducing …

How effective is R epoch?

With median follow-up times of 86 and 73 months, the overall survival rates were 100 percent and 90 percent, respectively, with DA-EPOCH-R and SC-EPOCH-RR.