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Is hydrochlorothiazide potassium depleting?

Is hydrochlorothiazide potassium depleting?

The drug has been widely used to treat hypertension globally and is relatively very safe. Hydrochlorothiazide acts on the distal convoluted tubules and inhibits the sodium chloride co-transporter system. This action leads to a diuretic action that lowers blood pressure, but there is also a potassium loss in the urine.

Why does HCTZ cause hypokalemia?

Thiazide diuretics cause hypokalemia; at the level of the pancreatic B cells, this hypokalemia causes hyperpolarization of the B cell and decreases insulin secretion. Decreased K in the interstitium keeps the K channels open for an extended time, which causes the hyperpolarization of the cell.

How much does HCTZ lower potassium?

The high dose produced a mean 0.7 mEq/L reduction in serum potassium while the low dose caused no change.

Does hydrochlorothiazide increase potassium?

By combining hydrochlorothiazide with triamterene, sodium and water are eliminated from the body without the loss of potassium. However, this drug may allow potassium levels to increase so potassium levels should be closely monitored.

Do you need to take potassium with hydrochlorothiazide?

If you take a low dose of chlorthalidone or hydrochlorothiazide and have normal kidney function, your doctor will probably recommend getting potassium from dietary sources. You can boost your potassium intake from the same foods that are heart healthy – vegetables, fruits and fish.

Which is better spironolactone or hydrochlorothiazide?

Spironolactone is superior to hydrochlorothiazide for blood pressure control and arterial stiffness improvement.

Does HCT cause diabetes?

Hydrochlorothiazide and chlorthalidone Hydrochlorothiazide (HCTZ) and chlorthalidone are diuretics used to lower blood pressure but may increase your risk for high blood sugar and diabetes.

Should I take potassium supplements with hydrochlorothiazide?