What can DNP be used for?

DNPs are used mainly as fungicides, herbicides, and insecticides. These compounds are extremely toxic to humans and other organisms. The mechanism of action involves disruption of oxidative phosphorylation by uncoupling the electrochemical gradient across the mitochondrial membrane.

When was DNP banned?

1938
Due to the sheer number of deaths of patients who were prescribed DNP, in addition to the other common and horrific AEs DNP provided, the drug was banned in the United States in 1938 and declared unfit for human consumption.

What happens when you consume DNP?

Symptoms of acute 2,4-dinitrophenol (DNP) poisoning include fever, dehydration, nausea, vomiting, restlessness, flushed skin and a rapid heartbeat. These can quickly progress to coma and death.

Why is DNP a poison?

DNP is a metabolic poison that acts by uncoupling oxidative phosphorylation, leading to uncontrolled hyperthermia. It is an illegal weight loss agent that is used by body builders and is freely available on many internet websites.

Is DNP drug legal?

Is it legal? It’s not illegal to possess DNP in the United States. However, a 2018 study showed that the sale of DNP is prohibited around the world, and DNP has never been approved by the FDA . Sellers of DNP can face heavy fines and jail time if caught.

Is DNP explosive?

DNP has also been used to make photographic developers and explosives (see shellite). DNP is classified as an explosive in the United Kingdom and the United States.

How do you treat DNP?

Overdoses of DNP are often fatal and there is no specific reversal therapy. Dantrolene interferes with calcium release in skeletal muscle and is traditionally used to treat malignant hyperthermia.

How long can you take DNP?

According to AACN, the recommended length of DNP programs is generally about three years on a full-time basis including summers or four years without summer study.