Where does aldosterone act on the nephron?

collecting ducts
It does so primarily by acting on the mineralocorticoid receptors in the distal tubules and collecting ducts of the nephron.

What activates the RAAS system?

Typically, RAAS is activated when there is a drop in blood pressure (reduced blood volume) to increase water and electrolyte reabsorption in the kidney; which compensates for the drop in blood volume, thus increasing blood pressure.

How does aldosterone regulate kidney function?

Aldosterone causes an increase in salt and water reabsorption into the bloodstream from the kidney thereby increasing the blood volume, restoring salt levels and blood pressure.

What is RAAS system in kidney?

Abstract. The renin-angiotensin-aldosterone system (RAAS) is a well known regulator of blood pressure (BP) and determinant of target-organ damage. It controls fluid and electrolyte balance through coordinated effects on the heart, blood vessels, and Kidneys.

What receptor does aldosterone bind to?

Aldosterone and Mineralocorticoid Receptors The mineralocorticoid receptor binds both aldosterone and cortisol with equal affinity.

What is the role of the antidiuretic hormone during RAAS?

ADH, or vasopressin, acts to increase water reabsorption in the kidney by inserting aquaporin channels at the collecting duct. Finally, angiotensin II decreases the sensitivity of the baroreceptor reflex.

How does the RAAS system cause hypertension?

The RAAS promotes oxidative stress in the brain, further activating the RAAS and augmenting sympathetic outflow. Angiotensin II and aldosterone of peripheral origin act in the brain to activate this cascade, increasing sympathetic outflow and leading to hypertension.

What controls the release of aldosterone?

Aldosterone is controlled by the renin-angiotensin system, while the rest of the adrenal glands’ hormone production is controlled by adrenocorticotropic hormone (ACTH).

What inhibits aldosterone release?

Aldosterone secretion may be inhibited by potassium depletion, inhibitors of the renin-angiotensin system, dopamine and atrial natriuretic factor. The latter appears to be an important physiological regulator of aldosterone secretion.

What happens to RAAS in CKD?

Sustained activation of the intrarenal RAAS in the presence of elevated arterial pressure leads to renal injury and plays a pivotal role in the pathogenesis of CKD.

Why does RAAS increase GFR?

The preferential increase in efferent resistance mediated by angiotensin II results in increased glomerular capillary hydraulic pressure, which maintains the glomerular filtration rate (GFR).

What stimulates aldosterone release?

angiotensin II
The major factors stimulating aldosterone production and release by the zona glomerulosa are angiotensin II and the serum potassium concentration. The juxtaglomerular apparatus is the principal site of regulation of angiotensin II production. Physiologic regulation of the renin-angiotensin-aldosterone axis.